Read e-book online Biotransformation and Metabolite Elucidation of Xenobiotics: PDF

By Ala F. Nassar

The target of this booklet is to enhance the readers' wisdom of metabolite elucidation in drug metabolism by way of exposing them to extensive insurance of the biotransformation of xenobiotics, ideas for determining and characterizing metabolites, FDA directions, and case stories on how one can enhance the decision-making procedure in structural amendment of drug applicants to lessen toxicity.

The ebook includes eight chapters; it first presents an creation on biotransformation of xenobiotics, after which provides glossy methods and techniques for facing metabolite characterization, utilizing instruments corresponding to LC-MS, H-D alternate, strong isotopes LC-MS-NMR, and radiolabeled compounds. additionally, concepts for facing reactive intermediates in drug discovery and improvement are offered in addition to case reports on bettering the decision-making procedure within the structural amendment of drug applicants. The final bankruptcy discusses the regulatory views of protection checking out of drug metabolites and why, how, and while to check their safety.

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Biotransformation and Metabolite Elucidation of Xenobiotics: Characterization and Identification by Ala F. Nassar

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