By Ala F. Nassar
The ebook includes eight chapters; it first presents an creation on biotransformation of xenobiotics, after which provides glossy methods and techniques for facing metabolite characterization, utilizing instruments corresponding to LC-MS, H-D alternate, strong isotopes LC-MS-NMR, and radiolabeled compounds. additionally, concepts for facing reactive intermediates in drug discovery and improvement are offered in addition to case reports on bettering the decision-making procedure within the structural amendment of drug applicants. The final bankruptcy discusses the regulatory views of protection checking out of drug metabolites and why, how, and while to check their safety.
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Biotransformation and Metabolite Elucidation of Xenobiotics: Characterization and Identification by Ala F. Nassar